The Bioelectrochemistry Group Leader
Prof. Dr. Ana Maria Oliveira Brett
Departamento de Química
Universidade de Coimbra
Tel (direct): +351-239-835295
BSc Chemistry University of Coimbra 1973
PhD, DIC Electrochemistry University of London, Imperial College 1980
DSc "Agregação" Chemistry University of Coimbra 2002
The research is centred on fundamental aspects in the areas of bioelectrochemistry, the study of electron transfer reactions of compounds of biological interest, and bioelectroanalysis, the development of enzymes and DNA biosensors. Current efforts include studies of the morphology of DNA adsorbed at solid charged interfaces, electrochemical detection of the mechanisms of DNA-drug interactions and evaluation of oxidative damage caused to DNA by health hazardous compounds. Related research is concerned with the study of electron transfer reactions of antioxidants and understanding the free-radical-induced damaging aspects of the chemistry of disease processes.
She is Professor in the Department of Chemistry of University of Coimbra.
She is a member of CEMMPRE, Research Unit 285 of Fundação para a Ciência e Tecnologia (FCT), and director of the Laboratory of Electroanalysis and Corrosion (IPN-LEC), Instituto Pedro Nunes, Coimbra.
She was the President of the International Bioelectrochemical Society (BES) for the period 2007-2015, and Past-President for the period 2016-2017. She was Associated Editor of the Journal Bioelectrochemistry, from 2000-2016.
She is Member of the Editorial Board of the International Journals: Bioelectrochemistry, Analytical Letters, Current Opinion in Electrochemistry, International Journal of Clinical Neurosciences and Mental Health, Journal of Research in Pharmacy.
She is a member of various Scientific Societies and has been an active member collaborating during different periods as Division Officer of Analytical Electrochemistry and of Bioelectrochemistry, in the International Society of Electrochemistry (ISE).
She is IUPAC Fellow, Fellow of the Royal Society of Chemistry (FRSC) and Chartered Chemist (CChem) (UK).
Research activity and collaboration with national and international groups is documented by projects and publications: more than 230 papers published, co-author of 2 undergraduate/graduate textbooks, both Oxford University Press (one also translated into Portuguese), 16 chapters in multi-author books, attending and presenting research work in research conferences, and has been invited to present more than 90 lectures including Plenary lectures in international conferences and invited Seminars.
ELECTROCHEMISTRY and BIOELECTROCHEMISTRY
Research projects are of a fundamental and applied nature, especially in the areas of Bioelectrochemistry and Bioelectroanalysis. They include electrodes modified by enzymes, peptides, proteins, or DNA, electrode reactions in flow systems and the study of electron transfer reactions of biologically relevant compounds:
- DNA-electrochemical biosensors, to investigate the interaction with DNA of hazard compounds, such as different types of anticancer drugs, toxic metals and herbicides.
- Mechanisms of electron transfer reactions of pesticides, anti-cancer drugs, antioxidants and drugs of abuse.
The research is centred on fundamental aspects in the areas of bioelectrochemistry, the study of electron transfer reactions of compounds of biological interest, and bioelectroanalysis. The development and applications of electrochemical DNA biosensors is enabling the electrochemical detection of the mechanisms of DNA-drug interactions, and evaluation of oxidative damage caused to DNA by health hazardous compounds. Morphological characterization of DNA adsorbed on charged solid interfaces is done by AFM.
Proteins are essential components of organisms and are involved in a wide range of biological functions. Oxidative damage to proteins is considered to be one of the major causes of aging and age-related diseases. Electrochemical studies in qualitative and quantitative analysis of proteins, and peptides related with Alzheimer's Disease, are providing different approaches to bioelectroanalytical sensing of biomolecules.
The direct electrochemical oxidation behaviour of proteins and study of protein-DNA interactions are being investigated. The interaction of DNA and proteins with solid electrode surfaces is not only a fundamental phenomenon but also a key to important and novel applications in biosensors, biotechnology, medical devices and drug-delivery schemes.
Additionally, electron transfer reactions of antioxidants are being studied in order to clarify the mechanisms of the damage induced by free radicals and the chemical reactions associated with the development of various diseases.
My URL: http://www1.ci.uc.pt/pessoal/anabrett/group_leader.htm
Link ORCID: http://orcid.org/0000-0002-6244-0891
Link Researcher ID: http://www.researcherid.com/rid/C-8936-2014
Link Scopus: http://www.scopus.com/authid/detail.url?authorId=7006682748
Link Google Scholar: https://scholar.google.com/citations?user=JW9NYWcAAAAJ&hl=en
Link Mendeley: https://www.mendeley.com/profiles/ana-maria-oliveira-brett/stats/
C.M.A. Brett and A.M. Oliveira Brett
Electrochemistry. Principles, methods and applications
Textbook, Oxford University Press, Oxford, 456 pages, June 1993. 2nd printing 1994, 3rd printing 1996, 4th printing 1998.
A.M. Oliveira Brett and C.M.A. Brett
Electroquímica. Princípios, métodos e aplicações
Translation published by Livraria Almedina, Coimbra, 496 pages, December 1996.
C.M.A. Brett and A.M. Oliveira Brett
Textbook, Oxford University Press, Oxford, 96 pages, October 1998.